Disclaimer:
For research use only. Not for human consumption. Intended for laboratory-based studies by qualified professionals. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.
 
Overview:
NAD⁺ is a vital coenzyme present in all living cells, playing a central role in energy metabolism, cellular repair, and longevity research. It functions as a key redox carrier in mitochondrial respiration and is essential for the activation of sirtuins and PARPs—enzymes linked to DNA repair, metabolic regulation, and aging processes.
Mechanism of Action:
NAD⁺ serves as a cofactor in oxidative phosphorylation and the Krebs cycle, enabling efficient ATP production. It also acts as a substrate for sirtuin deacetylases (SIRT1–SIRT7), which regulate gene expression related to stress response, inflammation, and energy homeostasis. In addition, NAD⁺ supports poly(ADP-ribose) polymerase (PARP) activity for DNA repair, maintaining genomic stability under oxidative stress.
Research has shown that NAD⁺ levels decline with age, leading to mitochondrial dysfunction and reduced cellular resilience, making it a major focus in longevity and metabolic optimization studies.
Research Highlights:
Demonstrated restoration of mitochondrial efficiency and cellular metabolism in preclinical models.
Shown to activate sirtuin pathways associated with DNA repair and longevity.
Studied for potential benefits in metabolic function, neuroprotection, and muscle recovery.
Investigated in combination with NAD⁺ precursors such as NMN and NR for comparative bioavailability research.
Specifications:
Form: Lyophilized powder or capsules (research-grade)
Purity: ≥99% (HPLC-tested)
Storage: Store in a cool, dry place (2–8 °C), sealed and protected from moisture and light.